Classics in Total Synthesis. By K.C. Nicolaou and E. J. Sorensen. Article (PDF Available) in Molecules 3(2) · February with 2, Reads. This book is essential for any synthetic organic chemist.[ ]. K. C. NICOLAOU, E. J. SORENSEN. CLASSICS IN. TOTAL. Page 2. Classics in Total Synthesis K. C. Nicolaou and. – E. J. Sorensen. VCH.

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The selected examples cover a large range of methods and very important natural products.

KGaA – Provider – www. Both, the retrosynthetical analysis and classifs actual reaction sequence up to the natural product are described in detail and in an accurate language.

Classics in Total Synthesis III

The introductions to the chapters often feature insights into nicolaoh biosynthesis of the natural product concerned e. Likewise, the third volume of this series, published by Wiley-VCH in Februarywill surely continue the success of the previous volumes, and will certainly be a must-have in the libraries of synthetically orientated groups.

After two years as a medicinal chemist at Enanta Pharmaceuticals, he began graduate studies at The Claxsics Research Institute under the guidance of Professor K. A wonderful tool for learning and teaching and a must-have for all current and future organic and biochemists.

Book Review: Classics in Total Synthesis – K. C. Nicolaou, E. J. Sorensen

Important reactions are additionally deepened. Graduate students and researchers alike will find this book a gold mine of useful information essential micolaou their daily work. Nicolaou – Winner of the Nemitsas Prize in Chemistry This book is a must for every synthetic chemist. After two years as a medicinal chemist at Enanta Pharmaceuticals, he began graduate studies at The Scripps Research Institute under the guidance of Professor K.

Site Search any all words Main Categories. Special emphasis is placed on the skillful use of graphics and schemes: Description Content Reviews Author information Retaining his excellent, proven approach, world-famous chemist and passionate teacher K. The review of asymmetric halogenation reactions Chapter Nicolaou compiles in this textbook synthsis important synthetic methods that lead to a complex molecule with valuable properties.


His impact on chemistry, biology and medicine flows from his research works in chemical synthesis and chemical biology inn in numerous publications and patens. Would you like to change to the site? It is amazing, synthesks in the 50’s, how projects like the synthesis of penicillin were advanced.

As the selection of synthetic target molecules for this book is exclusively taken from the more recent literature, in contrast to the first volume of the series, it remains to be seen whether the syntheses described will eventually become true classics. Didactically skillful approach, reflecting the world-wide standard way of tottal organic synthesis introduction, retrosynthetic analysis, synthesis.

Clasxics small sections describe problems associated with structure elucidation, which then led to revision of the supposed structure in the context of the total synthesis e. Using his didactically skillful approach, K. Every synthetic organic chemist will want to have a copy on his or her desk.

For a total of 42 syntheses of 25 challenging natural products he explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections for easier understanding, and contrasting these to other synthetic methods. Novelties of this third volume compared to the previous ones are mainly concerned with the detailed contents.

The depth of mechanistic discussions has been greatly increased.

He currently is a post-doctoral fellow in Professor Nicolaou’s laboratory. With didactic skill and clarity, K. Short Description Using his didactically skillful approach, K.

Important formulas are, in addition, depicted in the margin, next to the passage where they are mentioned in the text. His impact on chemistry flows from his works in chemical synthesis and chemical biology described in over publications and 55 patents.


All the key steps of the synthetic pathway are explained, with major developments highlighted in blue boxes. Read the press announcement: However, the opportunity to similarly illustrate other parts of the chapter has not been taken; especially in the introduction, figures or graphics in color might have improved the accessibility of the contents.

All literature references are clearly identified by chapter endnotes, thus allowing rapid access to the primary sources. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Planning, current methods and even the development of completely new synthesis methods are required, because the tools of nature are many times not available or are completely unknown!

He currently is a post-doctoral fellow in Professor Nicolaou’s laboratory. One innovation is the introduction of a colored title page at the beginning of each chapter, presenting an attractive graphical illustration of the target structure, together with its natural source and a picture of the leader of the group that worked on the total synthesis.

Classics in Total Synthesis: This alone is one of the great strengths of the book, and provides every synthetic chemist with an excellent pool for the solution of his or her own synthetic problems. Would you like to change to the site?

And due to the excellent presentation of reaction mechanisms and very good explanations of selected reactions, it is a beautiful teaching material for the advanced student, in order to deepen the knowledge acquired in the study.

The present volume – and hopefully future books of this series – offer an exciting and outstanding overview of the subject of natural products total syntheses in nciolaou complexity and variety. About the Author K. NicolaouJason S.