KLUCEL LF PDF

Klucel™ LF Pharma, SDS · TDS*. Klucel™ M CS, Klucel™ M CS has excellent film-forming properties and thickens non-aqueous systems and provide lubricious. Klucel hydroxypropylcellulose (HPC) provides a remarkable set of physical properties for tablet binding, modified release, and film coating. This unique polymer. Klucel hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with Klucel HPC is soluble in many polar organic solvents and in water below.

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HME process involves mixing of molten drug and polymers resulting in formation of a solid solution or dispersion of drug in a polymer matrix.

Klucel® Hydroxypropylcellulose LF

HPC is a long-chain, viscoelastic polymer that can expand or contract owing to flexibility of its polymer chains. Further processing might thus be required to manufacture a final dosage form that can be administered to a patient. The processing steps involved in manufacturing solid dispersions might induce a physico-chemical transformation, and hence, stability assessment is of pivotal importance.

HME conditions including barrel temperature and screw speeds were optimized for maximum yield and were set according to observations made from thermal studies. Ketoprofen KPR is a non-steroidal anti-inflammatory drug commonly used in treatment of pain and inflammation.

The pellets were evaluated for post-extrusion content using HPLC method. Disintegration testing was performed on a Dr. Formulation studies of a poorly water-soluble drug in solid dispersions to improve bioavailability.

This increased compactibility also resulted in increased tensile strength and has been further detailed in the tablet characterization section.

The difference could be attributed to absorption of moisture onto tablets that affected the disintegration time and hence a slower release at high humidity conditions. The influence of guaifenesin and ketoprofen on the properties of hot-melt extruded polyethylene oxide films. Work done in our lab earlier reported that rate of solubilization of HPC is kklucel upon polymer molecular weight However, UL assumes no responsibility or liability for the accuracy of the information contained on this website and strongly encourages that upon final product or material selection information is validated with the manufacturer.

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Support Center Support Center. Conversion to a high-energy amorphous llucel, being one of them, can also impart enhancement in solubility and hence bioavailability 9 Technologies such as solid dispersions have proven viable and been used extensively due to inherent advantages over other technologies 1.

Scanning electron microscope SEM was used to study surface morphology of extruded pellets.

In vitro Release Studies—Tablets HME exerts compression on molten material that results in densification and a subsequent decrease in porosity. Improving drug solubility for oral delivery using solid dispersions. The dissolution profiles are presented in Fig. Eur J Pharm Sci.

Klucel™ Hydroxypropylcellulose

The increased ability to form compacts can be attributed to increased plasticity of the extruded material Also, the smaller chains in ELF might have contributed towards a lesser elastic recovery, and hence, no capping was observed at higher compaction pressures for un-extruded tablets TT andTT. The dented appearance was formed due to rapid solubilization of hydrophilic excipients by an inward-moving solvent front. Smaller-chain-length ELF polymer hence klhcel less elastic recovery and higher plasticity and undergoes a greater deformation, forming lt compacts on being compressed.

The content of such third party sites is not within our control, and we cannot and will not take responsibility for the information or content. Interest in hydrophilic polymer-based solid dispersions has gained interest over the last decades due to solubility related issues with conventional formulations. Earlier studies performed on HPC HF, a higher molecular weight grade of HPC, report the advantages of using plasticizers l plasticizing effect of drugs This conversion is a drug-related attribute and beyond the klycel of this research work.

The extrusion conditions employed maintained MNT in a crystalline state confirmed by DSC studiesproviding a necessary backbone for the pelletization and milling operations. Are you a distributor who is interested in being listed here?

Magnesium stearate was purchased from Mallinckrodt. It was also observed that during extrusion process these formulations exhibited decreased die swelling.

Import Data and Price of klucel lf pharm | Zauba

Change in packaging or use of desiccant might help in overcoming these factors. Assay for tablets was performed by disintegrating the tablets in water and extracting the drug in methanol prior to being injected on the Olucel. Most of these techniques are multiple-batch processes that might also involve the use of organic solvents. However, such high energy forms tend to recrystallize or precipitate out from their supersaturated solutions.

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The chemicals used were of analytical grade and obtained either from Fisher Ld or Spectrum Chemicals.

It combines organic solvent solubility, thermoplasticity, and surface activity with the thickening and stabilizing properties of other water-soluble cellulose polymers. This article has been cited by other articles in PMC. The test fails to register the dynamics at point of failure, and hence, a texture analyzer was utilized to analyze the process of a tabletting breaking.

Based on results obtained from thermal studies, it was confirmed that KPR forms a solid solution with HPC polymers, and they were found to be miscible with each other. KPR melting peak was not observed in the second reheating step which confirmed formation of an amorphous KPR. This densification leads to a delayed disintegration and also decreased surface area. A single Tg and a crystalline peak for MNT were observed in the thermograms confirmed the physical state of component systems.

Among the extruded tablets, W f was higher for extruded tablets. A TA-8 ball probe was used to exert diametrical force on a vertically placed tablet. Compaction profiles were generated for extruded and un-extruded KPR formulations as per their definitions The extruded systems had an almost similar tabletting property to un-extruded blends.

Many polymers have been evaluated for use in HME including hydroxypropylcellulose HPC 17polyvinyl pyrrolidone 18polyethylene oxide 19and sugars such as isomalt 20erythritol 21and mannitol